Quercetin | Sanctuary Functional Medicine
Quercetin finds itself in a number of Sanctuary protocols due to the multiplicity of benefits it has to offer. The natural substance boasts among its most well known functions effects in ameliorating allergies, preventing oxidation of LDL cholesterol, assisting in metal detoxification, and providing anti-oxidant protection. Lesser known benefits include in prostatitis and very mild effects on lowering blood pressure and blood sugar. 2020 has highlighted its anti-viral effects as many use it in COVID 19 protocols.
Summaries of effects:
Allergies: The easiest and most common use of quercetin comes up when helping patients overcome a variety of allergies. Whether suffering from sinus issues, food sensitivities, or mast cell activation, quercetin can help shift our bodies away from the histamine which underlies allergic reactions. On one hand, it can inhibit release of histamine from mast cells (immune cells). On another hand, it can also lower IgE reactions which trigger histamine release.
Controlling mast cells and their subsequent release of histamine ranks high in the therapy for mold toxicity. Quercetin serves this otherwise difficult hurdle to therapy. It stabilizes mast cells so that they are less likely to release histamine or other immune stimulating chemicals.
In regular, old-fashioned allergies, many long-term allergies sufferers who have been dependent on anti-histamines and nasal steroids find that they can often wean off these pharmaceuticals partially or entirely.
Cholesterol: Oxidation of LDL cholesterol appears to underlie advancing atherosclerosis. Once oxidized, this LDL then triggers the immune system to cause arterial wall inflammation. By reducing LDL oxidation, atherosclerosis can be prevented. In a study by Graf et al, cardiovascular mortality was even reduced with quercetin intake. This seemed to be related to its scavenging free radicals and chelating metals.
While not confirmed, given that some research links mast cells and histamine to non-cholesterol related heart attacks, I wonder if quercetin is also acting through this mechanism as well.
Metals Detoxification: Quercetin remarkably finds a way to also protect animals from lead and cadmium toxicity through a variety of mechanisms. These include methallothionein, nitric oxide synthases (NOS), COX-2, MAPK, and NF-kappaB (see acronym key below)>
Antioxidant: Quercetin boasts major antioxidant capacity. It is comparable to curcumin in its scope.
Prostatitis: In one study, men who took quercetin 500mg twice daily for 1 month had a statistically significant improvement in prostate symptoms. 67% noted improvement versus only 20% of those on placebo therapy. Pain and quality of life improved but some urinary symptoms did not improve.
Blood Pressure and Blood Sugar: The effects on pressure and sugar are modest at best, but should be kept in mind when prescribing. The decrease in blood pressure was only 2-3 points in one study. The decrease in blood sugar was barely noticeable in another study while another did not show changes at lower doses.
Viral effects: With 2020’s excessive attention to anti-viral therapy thanks to COVID 19, several studies relating quercetin’s anti-viral effects deserve attention. A few studies indicate that quercetin may be preventive or therapeutic with a variety of viral infections.
Other areas being researched but without adequate support for recommendations:
How To take quercetin:
Potential side effects:
NF kappa B – Nuclear Factor kappa B. This protein plays a central role in promoting inflammation. A wide variety of triggers set off a cascade of downstream processes that all begin with NF kappa B. Once NK kappa B is triggered, these downstream processes carry out the metabolic pathways which produce what we perceive as inflammation.
COX-2: Cyclo-oxygenase 2 enzyme. This enzyme plays an important role in the inflammatory pathway. By converting arachidonic acid, an omega 6 fatty acid associated with inflammation, into prostaglandins, COX-2 sets off a cascade of processes leading to prostaglandins which cause inflammation. While a similar enzyme called COX-1 is always working at a relatively consistent low level, COX-2 is activated with inflammation.
NOS: inducible Nitric Oxide Synthase. This is one of the three enzymes responsible for producing nitric oxide in the body. NOS2 is the gene which produces this enzyme. This form is found in immune cells that are used to attack invaders like bacteria with oxidation. NOS is inducible because it is turned on when a need for immune defense is identified but turned down when the perceived threat is over.
Weng, Zuyi et al. “Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans” PloS one vol. 7,3 (2012): e33805.
Mlcek, Jiri et al. “Quercetin and Its Anti-Allergic Immune Response.” Molecules (Basel, Switzerland) vol. 21,5 623. 12 May. 2016, doi:10.3390/molecules21050623
Jafarinia, Morteza et al. “Quercetin with the potential effect on allergic diseases.” Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology vol. 16 36. 14 May. 2020, doi:10.1186/s13223-020-00434-0
Chirumbolo, Salvatore. “The role of quercetin, flavonols and flavones in modulating inflammatory cell function.” Inflammation & allergy drug targets vol. 9,4 (2010): 263-85. doi:10.2174/187152810793358741
Kashiwabara, Misako et al. “Suppression of neuropeptide production by quercetin in allergic rhinitis model rats.” BMC complementary and alternative medicine vol. 16 132. 20 May. 2016, doi:10.1186/s12906-016-1123-z
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Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation.
Garelnabi M1, Mahini H1, Wilson T1.
Frontiers in Pharmacology. 2017 Feb 3;8:40. doi: 10.3389/fphar.2017.00040. eCollection 2017.
Quercetin Inhibits LPS-Induced Inflammation and ox-LDL-Induced Lipid Deposition.
Xue F1, Nie X2, Shi J3, Liu Q1, Wang Z4, Li X2, Zhou J5, Su J4, Xue M1, Chen WD6, Wang YD4.
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Hu P Quercetin relieves chronic lead exposure-induced impairment of synaptic plasticity in rat gentate gyrus in vivo. Naunyn Schlmiederbergs Archives Pharmacology 2008 Jul; 378(1): 43-51
Vicente-Sánchez C., Egido J., Sánchez-González P.D., Pérez-Barriocanal F., López-Novoa J.M., Morales A.I. Effect of the flavonoid quercetin on cadmium-induced hepatotoxicity. Food Chemistry. Toxicol. 2008;46:2279–2287. doi: 10.1016/j.fct.2008.03.009.
Morales A.I., Vicente-Sánchez C., Jerkic M., Santiago J.M., Sánchez-González P.D., Pérez-Barriocanal F., López-Novoa J.M. Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicology and Applied Pharmacology. 2006;210:128–135. doi: 10.1016/j.taap.2005.09.006.
Liu C.M., Zheng G., Ming Q., Sun J., Cheng C. Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway. Free Radical Research. 2013;47:192–201. doi: 10.3109/10715762.2012.760198.
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Antioxidant properties of quercetin.
Zhang M1, Swarts SG, Yin L, Liu C, Tian Y, Cao Y, Swarts M, Yang S, Zhang SB, Zhang K, Ju S, Olek DJ Jr, Schwartz L, Keng PC, Howell R, Zhang L, Okunieff P.
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Rezvan, Neda et al. “Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial.” Cell journal vol. 19,4 (2018): 627-633. doi:10.22074/cellj.2018.4577
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Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection
Xiangguo Qiu, Andrea Kroeker, Shihua He, Robert Kozak, Jonathan Audet, Majambu Mbikay, Michel Chrétien
Antimicrobial Agents and Chemotherapy Aug 2016, 60 (9) 5182-5188; DOI: 10.1128/AAC.00307-16
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Sanctuary Functional Medicine, under the direction of Dr Eric Potter, IFMCP MD, provides functional medicine services to Nashville, Middle Tennessee and beyond. We frequently treat patients from Kentucky, Alabama, Mississippi, Georgia, Ohio, Indiana, and more… offering the hope of healthier more abundant lives to those with chronic illness.
This content was originally published here.