Diabetes drug Metformin recalled due to high level of cancer agent

The diabetes drug Metformin hydrochloride has been recalled because it contains excess levels of a cancer-causing agent, the U.S. Food and Drug Administration announced this week.

The drug’s manufacturer, Marksans Pharma Limited, has expanded a recall initially announced in June to now include an additional 76 unexpired lots of the medication.

The recalled drugs are marketed as “extended-release tablets” under the brand name Time-Cap Labs, Inc.

The drug helps lower the blood glucose levels of those with type 2 diabetes.

But the recalled product contained an unacceptably high level of N-Nitrosodimethylamine, which is considered a probable human carcinogen.

“Marksans performed N-Nitrosodimethylamine (NDMA) testing of unexpired identified marketed lots and observed that NDMA content in some lots is exceeding the acceptable Daily Intake Limit (ADI) of 96ng/day,” the FDA outlined in its announcement.

“Therefore, out of an abundance of caution, an additional 76 lots are being recalled.”

The recall applies to metformin tablets between 500 mg and 750 mg.

The 500 mg tablets are debossed with “101” on one side; the 750 mg tablets are debossed with “102” on one side, the agency said.

US health regulators are telling five drugmakers to recall their…

The FDA advises users to continue taking the recalled tablets until a medical professional provides a replacement or alternative treatment option.

“It could be dangerous for patients with type 2 diabetes to stop taking their metformin without first talking to their health care professional,” the FDA said in a statement.

Consumers “should contact their physician or healthcare provider if they have experienced any problems that may be related to taking or using this drug product.”

This content was originally published here.


Beer belly raises the risk of early death from illnesses such as type 2 diabetes and heart disease | Daily Mail Online

Having a beer belly raises the risk of premature death – even if the rest of your body is slim, research shows.

But having broad hips or larger thighs can help us to live longer, the study said.

Researchers looked at data from more than 2.5million people and found that every extra 4in (10cm) of waist size was associated with an 11 per cent higher chance of dying prematurely.

Many academics believe waist circumference is a more accurate indicator of obesity, and risk for illnesses such as type 2 diabetes and heart disease, than the commonly-used body mass index (BMI). 

Researchers looked at data from more than 2.5million people and found that every extra 4in (10cm) of waist size was associated with an 11 per cent higher chance of dying prematurely (file image)

This is because fat around the waist – or ‘visceral fat’ – sits around vital organs including the liver, kidneys, intestines and pancreas.

The new study was published in the British Medical Journal.

Study author Tauseef Ahmad Khan, from the department of nutritional sciences at the University of Toronto, said: ‘People should be more concerned about their waist rather than focusing only on weight or BMI.

Is diabetes pill key to dementia fight? 

A common diabetes pill taken by more than three million Britons may prevent dementia, research has suggested.

A study found that patients who took metformin, sold under the name Glucophage, have slower rates of mental decline and dementia.

Metformin is used to treat type 2 diabetes, which affects nearly four million in the UK. The study looked at 1,037 Australians aged 70 to 90 of whom 123 had type 2 diabetes. Those taking metformin had much better brain function and lower dementia risk compared to those not taking the drug.

Author Professor Katherine Samaras, of the Garvan Institute in Sydney, said: ‘This study has provided promising initial evidence that metformin may protect against cognitive decline.’ 

‘Waist is a better indicator of belly fat and while one cannot target where one loses fat from, losing weight through diet and exercise will also reduce waist and therefore belly fat.’

Dr Khan added: ‘Belly fat is the fat that is stored around the organs in the abdomen and its excess is linked to high cholesterol, high blood pressure, heart disease, diabetes, and stroke. Therefore, having more belly fat can increase the risk of dying from these diseases.’

The researchers found that most measures of abdominal fat were ‘significantly and positively associated with a higher all-cause mortality risk’ even after BMI was taken into account.

They said: ‘We found that the associations remained significant after body mass index was accounted for, which indicated that abdominal deposition of fat, independent of overall obesity, is associated with a higher risk.’

But their findings suggested that thigh and hip circumference were ‘inversely associated with all-cause mortality risk’. 

Each 10cm increase in hip circumference was associated with a 10 per cent lower risk of death from all causes – and each 5cm increase in thigh circumference was associated with an 18 per cent lower risk.

Dr Khan said hip fat is considered beneficial and thigh size is an indicator of the amount of muscle.

The risks of belly fat were the same when accounting for BMI, suggesting that it increases a person’s chances of death regardless of their overall weight.

More than 70 health studies, which followed more than 2.5million people for between three and 24 years, were analysed by the researchers. 

The NHS says that, regardless of height or BMI, men should try to lose weight if their waist is above 37in (94cm), while women should do so if their waist is above 31.5in (80cm). 

Beer belly raises the risk of early death from illnesses such as type 2 diabetes and heart disease

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Creative Seamstress Makes Dresses With Insulin Pump Pockets For Girls With Type 1 Diabetes | The Diabetes Site News

This story originally appeared at LittleThings.

A seamstress in Hanover, Massachusetts, has a new, never-before-seen specialty. She makes dresses for little girls who are living with diabetes.

Julie Christian has been sewing for only the past year. She decided to start a second career after years as a police officer.

Originally, Julie’s dream was to make beautifully tailored suits for women. But last summer, she received an unexpected request from a little girl.

Ten-year-old Julia Looker has type 1 diabetes.

“I asked if she could make me a dress customized for a diabetic pump,” Julia recalled.

Julie agreed. She made a lovely floral dress with a pocket to hide the pump. There’s also a hole along the waist seam so Julia can feed the pump wire into the attachment on her leg.

“It’s really convenient,” Julia said. “I like it a lot.”

The dress allows Julia to wear a dress without having to wear shorts underneath to hold the pump.

Soon after, other moms of girls with type 1 diabetes heard Julia’s success story. They, too, started contacting Julie for customized dresses for their daughters. Julie had found her new calling.

“It wasn’t women’s suiting as I anticipated; it was a whole different idea,” she said.

Check out the video below to see her incredible creations!

This content was originally published here.


Experimental type 1 diabetes vaccine causes improvement in small study

n experimental therapy for type 1 diabetes, widely derided by mainstream diabetes researchers, lowered blood sugar levels to near normal, a small, ongoing trial found. Patients in the trial, whose blood sugar levels have remained near normal for five to eight years, take about one-third less insulin than they did before, reducing their risk of hypoglycemia, in which insulin lowers blood sugar to dangerously low levels.

The experimental treatment, a decades-old generic vaccine for tuberculosis called bacillus Calmette-Guérin (BCG), seems to alter both cellular metabolism and the immune system, said Dr. Denise Faustman of Massachusetts General Hospital, senior author of the study published Thursday in npj Vaccines. “This cheap, old vaccine is lowering blood sugar to levels never achieved before,” she said.

While the results, from only nine patients, must be replicated in a larger study, said Dr. Joseph Bellanti of Georgetown University Medical Center, “if what they found is true, they really have something here.” Bellanti, who was not involved in the research, said the study’s eight-year follow-up and use of a placebo control arm made him “cautiously optimistic” that two doses of the BCG vaccine “can decrease levels of A1c,” a measure of blood glucose that predicts the likelihood of serious complications such as stroke and kidney failure.

JDRF (formerly the Juvenile Diabetes Research Foundation), the Joslin Diabetes Center, and several university diabetes centers all declined to speak about Faustman’s results. She has been a voice in the diabetes wilderness for nearly two decades, angering the establishment diabetes community by pursuing low-tech research very different from more popular approaches, such as embryonic stem cells and immunosupression.

Critics have gone so far as to send letters to newspapers that covered her work apologizing to patients “on behalf of Dr. Faustman” for “having their expectations cruelly raised.” She has also struggled for funding, receiving much of her research support from the private Iacocca Family Foundation, rather than in federal grants.

In Faustman’s Phase 1 clinical trial, three participants with type 1 diabetes received two doses of BCG vaccine, a month apart. After the vaccine showed signs of effectiveness, an additional six patients were vaccinated five years ago, and 111 more recently. The new paper and a presentation scheduled for a meeting of the American Diabetes Association this weekend focus on the patients who have been followed for more than five years.

All of those patients who received BCG had a statistically significant change in hemoglobin A1c. A normal level is below 6. In the vaccinated patients, A1c levels fell from an average of 7.36 before the first dose to 6.18 after five years, holding almost steady at 6.65 in the eighth year. In patients receiving a sham injection, levels showed almost no change from their initial levels of 7.10: 7.07 in the fifth year and 7.22 in the eighth.

“We wanted it to be good, but we didn’t know it would be this good,” Faustman said.

All of the patients remain on insulin, she said, but less of it. They are also able to monitor their blood sugar less frequently, which can be several times an hour. (The standard of care is a continuous glucose monitor, in which a probe is inserted into the abdomen, plus an insulin pump.) “If we can gradually move people to where they can control their blood sugar, their minute-to-minute lifestyle can improve dramatically,” Faustman said.

The A1c reductions could also bring significant health benefits. Every 10 percent drop, research shows, reduces complications such as stroke and heart attack by about one-third. The BCG vaccine lowered A1c levels 9 percent to 16 percent.

The new paper describes how the BCG vaccine, which has been used for nearly 100 years against tuberculosis and is considered extremely safe, might affect diabetes. According to studies in mice, it has two effects. It alters the immune system so as to increase levels of T regulatory cells; T regs keep other immune cells in check, including those that attack the pancreas’s insulin-making cells — the root cause of type 1 diabetes. In addition, BCG alters metabolism so cells consume higher levels of glucose, drawing more of it out of the blood, in a process called aerobic glycolysis.

“The clinical effects and the proposed mechanism demonstrated are exciting and add to the emerging consensus that the BCG vaccine can have a lasting and valuable impact on the immune system,” said Dr. Mihai Netea of Radboud University Medical Center in the Netherlands, who was not involved in the study.

A Phase 2 clinical trial of BCG is currently underway at Mass. General. It is testing multiple BCG doses in 150 patients with longstanding type 1 diabetes.

Although many studies of BCG are underway around the world in diabetes and other autoimmune diseases, including multiple sclerosis, there has been little interest among U.S. researchers outside Faustman’s lab.

“There is not a lot of enthusiasm because we’re all rewarded for discovering for-profit drugs,” she said. “Potential funders come [to my lab] and ask, ‘How can we make money off this?’”

BCG, whose one licensed manufacturer in the U.S. is Merck subsidiary Organon Teknika, costs less than a dollar a dose. (Faustman used a strain made by Sanofi.) The U.S. market for insulin meters and insulin pumps is $20 billion. “With everyone thinking they need a pump and a meter, if you come along with an inexpensive vaccine that can change this standard of care, of course there will be pushback,” Faustman said.

This content was originally published here.


Wilford Brimley, Face of Quaker Oats & Diabetes Campaigns, Dead at 85

Brimley started out as mostly a TV actor, landing one-time roles on TV series like “How the West Was Won,” ‘Kung Fu,’ “The Oregon Trail,” and then eventually … a recurring part on “The Waltons.” He went on to star in a bunch of TV movies, such as “The Wild Wild West Revisited,” “Amber Waves,” “Roughnecks,” “Rodeo Girl,” ‘The Big Black Pill,’ and so on.

In the ’80s, he started breaking out into more traditional films, appearing in flicks like “High Road to China,” “10 to Midnight,” “Tough Enough,” “Jackals,” “End of the Line,” and a bunch of other B-movies where he’d often play an authority figure or a grandfatherly figure with his deep, comforting Southern accent. One of the best character actors without a doubt.

He went on to star in countless other movies and shows, notably on “Our House,” in which he starred in over 40 episodes, as well one-off appearances in hit series like “Walker, Texas Ranger,” “Seinfeld,” and so many others.

This content was originally published here.


Diabetes is actually five separate diseases, research suggests

Image copyrightGetty Images
Image caption Could there be five types of diabetes rather than just two?

Scientists say diabetes is five separate diseases, and treatment could be tailored to each form.

Diabetes – or uncontrolled blood sugar levels – is normally split into type 1 and type 2.

But researchers in Sweden and Finland think the more complicated picture they have uncovered will usher in an era of personalised medicine for diabetes.

Experts said the study was a herald of the future of diabetes care but changes to treatment would not be immediate.

Diabetes affects about one in 11 adults worldwide and increases the risk of heart attack, stroke, blindness, kidney failure and limb amputation.

Type 1 diabetes is a disease of the immune system. It errantly attacks the body’s insulin factories (beta-cells) so there is not enough of the hormone to control blood sugar levels.

Type 2 diabetes is largely seen as a disease of poor lifestyle as body fat can affect the way the insulin works.

The study, by Lund University Diabetes Centre in Sweden and the Institute for Molecular Medicine Finland, looked at 14,775 patients including a detailed analysis of their blood.

  • Cluster 1 – severe autoimmune diabetes is broadly the same as the classical type 1 – it hit people when they were young, seemingly healthy and an immune disease left them unable to produce insulin
  • Cluster 2 – severe insulin-deficient diabetes patients initially looked very similar to those in cluster 1 – they were young, had a healthy weight and struggled to make insulin, but the immune system was not at fault
  • Cluster 3 – severe insulin-resistant diabetes patients were generally overweight and making insulin but their body was no longer responding to it
  • Cluster 4 – mild obesity-related diabetes was mainly seen in people who were very overweight but metabolically much closer to normal than those in cluster 3
  • Cluster 5 – mild age-related diabetes patients developed symptoms when they were significantly older than in other groups and their disease tended to be milder
Image copyrightGetty Images

Prof Leif Groop, one of the researchers, told the BBC: “This is extremely important, we’re taking a real step towards precision medicine.

“In the ideal scenario, this is applied at diagnosis and we target treatment better.”

The three severe forms could be treated more aggressively than the two milder ones, he said.

Cluster 2 patients would currently be classified as type 2 as they do not have an autoimmune disease.

However, the study suggests their disease is probably caused by a defect in their beta-cells rather than being too fat.

And perhaps their treatment should more closely mirror patients who are currently classed as type 1.

Cluster 2 had a higher risk of blindness while cluster 3 had the greatest risk of kidney disease, so some clusters may benefit from enhanced screening.

Better classification

Dr Victoria Salem, a consultant and clinical scientist at Imperial College London, said most specialists knew that type 1 and type 2 was “not a terribly accurate classification system”.

She told the BBC: “This is definitely the future of how we think about diabetes as a disease.”

But she cautioned the study would not change practice today.

Dr Salem said: “There is still a massively unknown quantity – it may well be that worldwide there are 500 subgroups depending on genetic and local environment effects.

“Their analysis has five clusters, but that may grow.”

Sudhesh Kumar, a professor of medicine at Warwick Medical School, said: “Clearly this is only the first step.

“We also need to know if treating these groups differently would produce better outcomes.”

Dr Emily Burns, from Diabetes UK, said understating the diseases could help “personalise treatments and potentially reduce the risk of diabetes-related complications in the future”.

She added: “This research takes a promising step toward breaking down type 2 diabetes in more detail, but we still need to know more about these subtypes before we can understand what this means for people living with the condition.”

By James GallagherHealth and science correspondent, BBC News

This content was originally published here.


The Plant That Kills Cancer Cells, Stops Diabetes And Boosts Your Immune System!

When you think of melon, you probably think of long summer days spent on the beach or porch chewing on sweet, crisp fruit.

However, if you’re from the Caribbean or Asia, bitter melon may also come to mind.  The strange fruit may look like a lumpy cucumber or a sad gourd, but it’s one of the healthiest foods on the planet.

Traditional Uses

Bitter melon is typically used for to treat various stomach and intestinal disorders (1).

These include:

  • Upset stomach
  • Ulcers
  • Colitis
  • Constipation
  • Intestinal worms

It can also be used for kidney stones, fever, psoriasis, liver disease, menstrual pain and as a supportive treatment for HIV/AIDS.

Diabetic Care

Studies show that compounds found in bitter melon mimic insulin. They lower blood sugar by promoting the transportation of glucose into cells and the storage of energy in the liver and muscles.  The fruit improves insulin sensitivity, glucose tolerance and insulin signaling and can even help support weight loss (2).

Use In Cancer Patients

Surprisingly, the same actions that make the melon suitable for diabetics help kill cancer cells.

University of Colorado Cancer Center found that bitter melon stops pancreatic cancer cells from metabolizing glucose. This works because cancer cells need sugar to survive. Daily consumption of bitter melon juice was found to reduce pancreatic cancer risk by 60%. (3)

Bitter melon also displays cytotoxic activity. It contains a ribosome inhibiting protein (RIP) that induces apoptosis in prostate cancer cells (4). It also prevents the spread of cancer.In fact, mice fed bitter melon extract had a 51% reduction of cancer proliferation (5).

And these studies aren’t alone, the NIH reports that several groups of investigators have reported that treatment of bitter-melon-related products in a number of cancer cell lines induces cell cycle arrest and apoptosis without affecting normal cell growth (6).

The fruit has also shown positive results in treating leukemia, lung cancer, ovarian cancer, breat cancer and squamous cell carcinoma (skin cancer) (7,8,9,10).

Ratna Ray, Ph.D., professor of pathology at SLU hopes to continue to investigate the use of bitter melon for cancer treatment (11). Who knows, perhaps in a few years cancer patients will be given juicers instead of chemotherapy.

How To Use Bitter Melon

Healthy adults should not exceed two ounces of bitter melon a day. Larger quantities will cause abdominal pain and diarrhea (12). Children under 18, pregnant women and people taking insulin or hypoglycemic medication should not use bitter melon unless under strict medical supervision (12).

Page 1 / 2 >

This content was originally published here.


Diabetes: 40 million people will be left without insulin by 2030

Insulin is needed to treat all people with type 1 diabetes and some people with type 2 diabetes. The latter form of the disease is strongly linked to lifestyle factors such as obesity, poor diet and physical inactivity.
Basu’s team set out to explore how rates of diabetes will change over the next 12 years, namely by how much numbers will rise, in order to predict the amount of insulin that will be needed and whether everyone who needs it will have access.
Using data from the International Diabetes Federation and 14 studies to get a picture of type 2 diabetes numbers across 221 countries, the team modeled the burden of type 2 diabetes from 2018 to 2030.
They predicted that, worldwide, the number of adults with type 2 diabetes will rise from 406 million in 2018 to 511 million in 2030. The United States will have the third highest numbers globally, with 32 million people predicted to be living with the condition in 2030.
“The number of adults with type 2 diabetes is expected to rise over the next 12 years due to aging, urbanization and associated changes in diet and physical activity,” said Basu.
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However, not all people with diabetes require insulin. Of that global total of 511 million, 79 million were predicted to be in need of insulin to manage their diabetes — a 20% rise in the demand for insulin — and only 38 million are likely to have access to it based on current resources.
Insulin treatment is expensive and the market is currently dominated by three manufacturers, according to the study.
“Unless governments begin initiatives to make insulin available and affordable, then its use is always going to be far from optimal,” said Basu.

This content was originally published here.


VAT-free starting 2019: Medicines for diabetes, high cholesterol, hypertension

The tax exemption is part of the tax reform law signed in December 2017

This content was originally published here.


Sherri Shepherd Reveals Going A Year Without Sugar Has Reversed Her Type 2 Diabetes Diagnosis: “I Can’t Even Believe It!”

Celebrities Visit SiriusXM - February 6, 2019

Source: Slaven Vlasic / Getty

Ever since she decided to wean herself off of sugar last March, Sherri Shepherd has seen her health transform in tremendous ways. We’ve seen the weight loss and heard about the increased energy, but the 52-year-old also shared in an Instagram video on Monday that she was told by her doctor that her dietary changes have reversed her diabetes diagnosis. An A1C test (which is meant to identify one’s average blood glucose levels) that is above 6.5 is a sign of Type II diabetes. One that is between 5.7 and 6.4 is prediabetes. Sherri’s A1C level is now a 5.4.

“I just came back from the doctor’s office to get my A1C because I’m a Type 2 diabetic. In 2016, ’17 and ’18, my numbers were 6.6. The doctor prescribed Metformin for me. I just came out of the office and my numbers are 5.4,” she said. “The doctor said to me, ‘You’re not even prediabetic! What did you do?’ I can’t even believe it! I know it’s because I’ve been off sugar since March 2018, and it’s because Jeffrey said to me, ‘Mommy, if you die, who’s going to be my bodyguard?’ I can’t even believe this.”

The comedian and actress stated that all of the women in her family have struggled with and died from diabetes, so to get to this point with her own health is something she is overjoyed about.

“I lost my mom in her early 40s to diabetic complications,” she said in the same video. “I just lost my aunt. She had diabetes and she had her leg cut off. She died. Both my sisters are on insulin right now. It runs in my family. I just want to encourage you. You can take this journey to health. You can be healthy. Who are you living for? Who needs you here? Oh my gosh, I’m so sorry I don’t have my eyelashes, my glam, my wig on, I just had to let you know, 5.4 from 6.6! You can do this! You can do it!”

Shepherd also thanked fans in her caption for their support, which helped her stay on track and as she put it, kick diabetes’ a–.

“I knew I had to make lifestyle changes or I would die,” she said. “I wanted to share this good news with you to say THANKYOU to each person who texted, posted and dm’d me encouragement throughout my road back to health. I feel so good right now I could scream.”

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#thankyoujesus #joy #workinghard #sugarfree #sugarfreelife #sherrishepherd #feelsgoodtofeelgood #takingcontrolofmyhealth #nomoremetformin #healthiswealth #kickingdiabetesass

A post shared by Sherri (@sherrieshepherd) on

Shepherd, for the record, is also a keto diet fan. She started it last July following her sugar banishment. All of her efforts and decisions have clearly paid off.

“Just want to encourage you that this can be done,” she said. “You have people who love you and need you to be here. Live for you! Live for them!”

This content was originally published here.