keto diet

High fat or ‘ketogenic’ diets could prevent, reverse heart failure

High fat or 'ketogenic' diets could prevent, reverse heart failure
Kyle S. McCommis, Ph.D., is an assistant professor in Biochemistry and Molecular Biology at Saint Louis University. Credit: Saint Louis University

Research from Saint Louis University finds that high fat or “ketogenic” diets could completely prevent, or even reverse heart failure caused by a metabolic process.

The research team, led by Kyle S. McCommis, Ph.D., assistant professor in Biochemistry and Molecular Biology at SLU, looked at a metabolic process that seems to be turned down in failing human hearts.

In an animal model, drastic heart failure in mice was bypassed by switching to high fat or “ketogenic” diets, which could completely prevent, or even reverse the heart failure.

“Thus, these studies suggest that consumption of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat heart failure,” McCommis said.

The findings, “Nutritional Modulation of Heart Failure in Mitochondrial Pyruvate Carrier-Deficient Mice” were published online Oct. 26 in Nature Metabolism. This research, which was initiated during McCommis’ postdoctoral and junior faculty positions at Washington University School of Medicine, then was completed at Saint Louis University School of Medicine.

The heart’s myocardium requires vast amounts of chemical energy stored in nutrients to fuel cardiac contraction. To maintain this high metabolic capacity, the heart is flexible and can adapt to altered metabolic fuel supplies during diverse developmental, nutritional, or physiologic conditions. Impaired flexibility, however, is associated with cardiac dysfunction in conditions including diabetes and heart failure.

The mitochondrial pyruvate carrier (MPC) complex, composed of MPC1 and MPC2, is required for pyruvate import into the mitochondria. This study demonstrates that MPC expression is decreased in failing human and mouse hearts, and that genetic deletion of the MPC in mice leads to cardiac remodeling and dysfunction.

“Interestingly, this heart failure can be prevented or even reversed by providing a high-fat, low carbohydrate “ketogenic” diet,” McCommis said. “A 24-hour fast in mice, which is also “ketogenic” also provided significant improvement in heart remodeling.”

Diets with higher fat content, but enough carbohydrates to limit ketosis also significantly improved heart failure in mice lacking cardiac MPC expression.

“Our study reveals a critical role for mitochondrial pyruvate utilization in cardiac function, and highlights the potential of dietary interventions to enhance cardiac fat metabolism to prevent or reverse cardiac dysfunction and remodeling in the setting of MPC-deficiency,” McCommis said.Ongoing studies will seek to uncover the importance of ketone body versus fate metabolism in this process of improved cardiac remodeling.


More information:
Kyle S. McCommis et al, Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice, Nature Metabolism (2020). DOI: 10.1038/s42255-020-00296-1

Journal information:

High fat or ‘ketogenic’ diets could prevent, reverse heart failure (2020, October 26)
retrieved 26 October 2020
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

This content was originally published here.

functional medicine

Naples Center for Functional Medicine now offers FastVitaminIV therapy service – Naples Center for Functional Medicine

Set iv fluid intravenous drop saline drip hospital room,Medical Concept,treatment emergency and injection drug infusion care chemotherapy, light backgroundNaples Center for Functional Medicine has expanded its IV therapy services to include FastVitaminIV. The proprietary blend contains 19 health-promoting vitamins, minerals and amino acids. 

FastVitaminIV is the newest adjunctive medical service at Naples Center for Functional Medicine. Patients report feeling a “push effect” after receiving FastVitaminIV treatments. Those feelings include a surge of energy, sensation of general happiness and a boost in mental clarity and focus. 

What are IV therapies? 

Quick-acting and more effective than oral supplements, IV therapy infuses nutrients intravenously into the bloodstream. This allows a patient’s body to bypass the need for absorption through the intestinal tract. Instead, their body can immediately begin using, and benefiting from, the liquid nutrients. 

What is FastVitaminIV? 

Developed by Koniver Wellness,  is a blend of 19 vitamins, minerals, and amino acids. It is administered intravenously for about one minute, much faster than traditional IV drips that take 30 to 120 minutes. 

What are the health benefits of FastVitaminIV? 

Patients report improved moods, boosted energy levels, elevated concentration and focus, better sleep and an overall improved sense of well-being. Additional benefits may include improved athletic performance and recovery, relief for hangovers and migraines, and anti-aging properties. 

What do patients experience and feel during a treatment? 

Patients receiving a FastVitaminIV treatment may experience these feelings and sensations, in order: 

Just as quickly as these symptoms set in, they are gone. The whole process takes about one minute from start to finish. 

FastVitaminIV notes that patients “have NEVER EVER had an adverse reaction from FastVitaminIV.” 

What other IV therapies are available at Naples Center for Functional Medicine? 

In addition to FastVitaminIV, Naples Center for Functional Medicine’s other IV therapies include brain optimization, chelation therapy, glutathione, high-dose vitamin C, hydration, nutritional and ozone therapy. Registered nurses perform IV therapies in the center’s infusion lounge. All patients are first seen by a doctor at Naples Center for Functional Medicine to determine appropriate therapy. 

IV therapy is one many services available to patients at Naples Center for Functional Medicine. Other services include Nutritional Analysis, Functional Diagnostic Testing, IV Therapy, Supplement Therapy, Hyperbaric Oxygen Therapy and IntellxxDNA Genetic Testing. 

In a recent news article, , medical director at Naples Center for Functional Medicine, had this to say about IV therapies: 

FastVitaminIV therapy is a safe, effective way to deliver vitamins and minerals that help a person’s body and mind perform at optimum levels,” she said. “More patients are turning toward IV therapy because it allows nutrients to enter the bloodstream directly, so they’re seeing nearly instantaneous results.” 

As always, consult with your physician prior to making any substantial lifestyle, health or nutritional changes. For questions, please contact our office at  or submit an appointment request through our . 

This content was originally published here.

functional medicine

As A Functional Medicine Expert, This Is The Greens Powder I Use

Like any woman who has newly learned she is pregnant (or, at least, I think this is a common sentiment?) I became immediately protective over what I put in my belly. But with the nausea, headaches, fatigue, and hellish rollercoaster of a first trimester, all I was able to stomach was yogurt, mac and cheese, cheese, and grilled cheese (you can pick up a theme here). I was positive my baby was going to come out looking like a wheel of brie. 

So I tried eating a salad one day. I vomited that right up. Then some cooked broccoli. Not a chance that stayed down. I managed to successfully eat peas and butter with a lot of effort and some acupuncture (I was determined that day and had a little extra time on my hands). But all in all, I wasn’t getting anywhere near my usual intake of 10 to 12 veggies a day, and all I kept seeing was my adorable little unborn child with a block of cheddar for a head.

So I posed the question: How do I get a sufficient amount of organic veggies every day, without having to cook them or eat them? It finally dawned on me that greens powder was the way to go.

I eagerly kept an eye on the mailbox until my delivery of organic veggies+ powder arrived—I was so excited to finally gobble down nutritious veggies, without gagging on a salad. As soon as it arrived I tried it three different ways: with just water, with pineapple juice, in a smoothie.

When I mixed it with water, it didn’t taste awful (huge score!)—the drink went down easy and helped to move things right along.* The pineapple and water combo was probably my fav because it added a teeny bit of sweetness and made me feel like I was on vacation (very important when you haven’t been out of the house in months). In the smoothie, it didn’t have an overbearing greens taste, and I was even able to sneak it into my boyfriend’s morning smoothie without getting an eye roll, which was a big bonus.

Once I established I liked the taste and I could feel it doing positive things in my body,* I dug a little deeper into what was really in the powder, and what set it apart from the others. Here were my big takeaways:

This content was originally published here.


CDC Study Finds Overwhelming Majority Of People Getting Coronavirus Wore Masks

A Centers for Disease Control report released in September shows that masks and face coverings are not effective in preventing the spread of COVID-19, even for those people who consistently wear them.

A study conducted in the United States in July found that when they compared 154 “case-patients,” who tested positive for COVID-19, to a control group of 160 participants from the same health care facility who were symptomatic but tested negative, over 70 percent of the case-patients were contaminated with the virus and fell ill despite “always” wearing a mask.

“In the 14 days before illness onset, 71% of case-patients and 74% of control participants reported always using cloth face coverings or other mask types when in public,” the report stated.

In addition, over 14 percent of the case-patients said they “often” wore a face covering and were still infected with the virus. The study also demonstrates that under 4 percent of the case-patients became sick with the virus even though they “never” wore a mask or face covering.

Despite over 70 percent of the case-patient participants’ efforts to follow CDC recommendations by committing to always wearing face coverings at “gatherings with ≤10 or >10 persons in a home; shopping; dining at a restaurant; going to an office setting, salon, gym, bar/coffee shop, or church/religious gathering; or using public transportation,” they still contracted the virus.

While the study notes that some of these people may have contracted the virus from the few moments that they removed their mask to eat or drink at “places that offer on-site eating or drinking,” the CDC concedes that there is no successful way to evaluate if that was the exact moment someone became exposed and contracted the virus.

“Characterization of community exposures can be difficult to assess when widespread transmission is occurring, especially from asymptomatic persons within inherently interconnected communities,” the report states.

In fact, the report suggests that “direction, ventilation, and intensity of airflow might affect virus transmission, even if social distancing measures and mask use are implemented according to current guidance.”

Despite this new scientific information, the CDC, Director of the National Institute of Allergy and Infectious Diseases Dr. Anthony Fauci, and many political authorities are still encouraging people to wear masks. Many states and cities have even mandated masks, citing them as one of the main tools to “slow the spread” of coronavirus and keep case numbers in their area down.

CDC Director Dr. Robert Redfield makes it as clear as he can: “This face mask is more guaranteed to protect me against COVID than when I take a COVID vaccine.”

— The Recount (@therecount) September 16, 2020

This content was originally published here.

functional medicine

CDC Can’t Operate A Stick Shift | Sanctuary Functional Medicine

The long-standing debate between automatics and stick shifts in cars has taken a whole new twist as the nation’s health experts at the CDC can’t seem to choose “drive” or “reverse” as they release guidance on various aspects of their COVID 19 response. Two articles from Medscape highlight this inability to avoid appearing like a 16 year old trying to drive a stick shift for the first time.  The car lurches backwards and forwards in fits and starts and loud noises.  The CDC likewise has lurched back and forth between different assertions and recommendations.  It’s a wonder that we are feeling just like the parent teaching the 16 year old to drive, a little car sick and dizzy.

To be fair, this whole fast paced pandemic research process publicized on international news deserves acknowledgement that science moves forward in fits and starts.  Researchers work for years and then lunge forward with a new breakthrough, but then in another area new research overturns past theories seemingly sending us backwards or at least sideways.  Normally these fits and starts of scientific breakthrough are not noticed by the general public.  A few get media attention, but the vast majority are only recognized by those deep in that field of science.

With COVID 19, any breakthrough regardless of significance can be virally spread across the globe in hours only to be overturned days or weeks later with a different “breakthrough”.  We can’t completely blame the CDC for the fast-paced changing landscape of COVID 19 knowledge.  However, we can blame them for confusing us to no end with their hokey pokey exploits.  They put their recommendations in and take them out and put them in again.

But this is not a game.  This is about lives at stake, both in terms of life versus death and the economic livelihoods of millions when recommendations include lock-downs.  We expect experienced drivers who can shift the gears from one scientific discovery to the next without giving us whiplash.

In one Medscape article, they discuss how the CDC changed their stance on whether or not exposed individuals without symptoms should or should not get tested.  Some claim that the Trump administration made this a political issue when they urged against testing the asymptomatic.  Many pushed back saying this would hinder public health infection control measures.  In other media and social media outlets not mentioned, many agreed that testing asymptomatic individuals was overkill.  In the end, who really knows what they are thinking.  We have to discern as best we can with the information provided whether testing asymptomatic individuals is good or bad.  I see arguments on both sides of the fence.

In another Medscape article, a hokey pokey guideline comedy is retold.  The CDC initially released “new” guidelines stating that SARS CoV 2 is spread by aerosol droplets. This would mean that the droplets coming out of an infected patient’s mouth and nose were floating around in a room longer than just being a projectile that traveled 6 feet and fell on the ground.   Then, in a “turn yourself about” kind of move, they took them back and said it was an accidental release of draft guidelines.  My question, did someone at least get their hand slapped for misleading over 300 million Americans with this “oops”.  Try this next time you turn in a college research paper.  After you get a C+, tell your professor, that you “accidentally” turned in a draft and will be “resubmitting” a final version very soon.  Ludicrous in both situations.

In both situations, the CDC can’t resort to the excuse of rapidly changing science on COVID 19.  They need more transparency.  They need more forethought.  They need to apply wisdom.  They need to say they are sorry.  AND they need to learn how to use a stick shift.

One other good thing can be gleaned from this.  The second Medscape article ends their summary of the comedy with noting that the update included a new recommendation to use air purifiers to “help reduce airborne germs in indoor spaces.”  At least we can agree on that since our clinic was running Austin Air and Air Oasis purifiers prior to the epidemic to lower toxic exposures and infectious exposures for our clinic patients.  A big part of helping others live healthier more abundant lives requires guiding patients smoothly through their health journey instead of following the CDC’s pattern of a teenage new stick shift driver.

CDC Reverses COVID-19 Testing Guidance Again: Exposed Without Symptoms Need Tests. Accessed 9/26/2020

CDC Adds Then Retracts Aerosols as Main COVID-19 Mode of Transmission. Accessed 9/26/2020

Sanctuary Functional Medicine, under the direction of Dr Eric Potter, IFMCP MD, provides functional medicine services to Nashville, Middle Tennessee and beyond. We frequently treat patients from Kentucky, Alabama, Mississippi, Georgia, Ohio, Indiana, and more… offering the hope of healthier more abundant lives to those with chronic illness.

This content was originally published here.

functional medicine

The Underrated Anti-Inflammatory Nutrient That Will Help You Live Longer, According to a Functional Medicine Doctor

As one of the top functional medicine doctors in the country, Frank Lipman, MD, is asked a wide range of health-related questions every single day. Sometimes they’re tied to something specific trending in the wellness space: Is collagen overrated? (Nope.) Is oat milk? (Possibly.) Other times, it’s about how to get a better night’s sleep. But all the queries seem to be rooted in an even bigger question: how to live a long, healthy life.

Longevity seems to be at the heart of every question he’s asked, so Dr. Lipman decided to write a whole book dedicated to the topic: ($20), out October 27, 2020. Tucked in the pages are some “rules” you’re likely familiar with, like cutting back on sugar and having a strong sense of purpose. But there are also some surprising things that have been scientifically linked to longevity that aren’t as widely talked about. One of those truth bombs is centered around an anti-inflammatory compound called quercetin.

Never heard of it? Quercetin is a polyphenol derived in plants that is connected to lowering inflammation, supporting the immune system, and, yes, longevity. “Besides curcumin, quercetin is one of the most important supplements for both immunity and longevity,” Dr. Lipman says. Looks like turmeric has some competition.

What is quercetin?

Before we dig deep into all the benefits quercetin boasts, it’s helpful to know what the heck it actually is. Dr. Lipman explains that quercetin is a type of polyphenol, which are micronutrients with antioxidant properties found in plants. Some foods that have this particular type of polyphenol are apples, onion, raspberries, red grapes, and cherries.

Quercetin has lots of benefits, but Dr. Lipman is most excited about its connection with longevity. “One is that it affects longevity gene pathways in a positive way, specifically activating AMPK [a protein enzyme],” he says. AMPK helps regulate cellular metabolism; when cellular energy is low, AMPK is called in for backup to keep the body running as it should. It also controls cellular autophagy, aka the clearing out of damaged cells. And recent research suggests that the enzyme can potentially delay the aging process as well. One paper published in the journal Discoveries states that AMPK activation increased the life of fruit flies by as much as 30 percent.

“Quercetin is anti-inflammatory, anti-viral, and immunity-boosting,” Dr. Lipman adds—properties that are important for longevity. To his point, chronic inflammation is associated with many age-related health problems, including cognitive decline and cancer, so managing inflammation is often seen as crucial for living a longer, healthier life. Meanwhile, the immune system weakens with age, making it harder for the body to fight off illness, so keeping it in tip-top shape is critical. Quercetin also supports gut health; since a huge portion of the immune system lies in the gut, “keeping your gut healthy is very important to immunity,” says Dr. Lipman.

Don’t worry curcumin, we still love you. Watch the video below to see why it’s so powerful: 

Despite quercetin being in such a wide range of plant-based foods, Dr. Lipman says most people don’t consume enough of it to truly benefit. Part of this is because most Americans don’t eat enough fruits and vegetables, but even foods that naturally contain quercetin don’t have very high doses of the polyphenol. This is why Dr. Lipman often recommends a quercetin supplement. (He actually has his own, Superpowder, $54, which he created for The Well as its chief medical officer.)

Other tips Dr. Lipman wants everyone to know about longevity

While certainly more studies need to be done on quercetin (particularly on humans, not fruit flies or rats), the evidence that suggests its connection to longevity is compelling. But Dr. Lipman reiterates that it, like anything else, certainly isn’t a silver bullet for being a healthy octogenarian.

“One of the most important things for longevity is getting enough sleep,” he says. “We have a glymphatic system in the brain, which is the brain’s self-cleaning mechanism, and it only works when you’re asleep.” Not getting enough sleep makes it harder for the glymphatic system to do its clean-up job, which over time can lead to cognitive decline, Dr. Lipman says.

He also emphasizes the importance of having a sense of purpose, regular exercise, and eating healthy overall. Doubling down on apples and onions or popping a daily quercetin supplement is no replacement for a healthy diet. “When you look at Blue Zones, where people regularly live into old age in good health, they eat foods that are close to nature and not overly processed, they have a good support system, and aging is actually revered,” Dr. Lipman says. “These things matter.”

When it comes to longevity, it’s not only about what you put into your body, but is also about what’s in your heart. While the benefits may be outward-facing, when you get down to it, longevity truly is an inside job.

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This content was originally published here.


Coronavirus: WHO joins the Great Barrington Declaration by condemning lockdowns

Dr. David Nabarro from the WHO appealed to world leaders yesterday, telling them to stop “using lockdowns as your primary control method” of the coronavirus.

He also claimed that the only thing lockdowns achieved was poverty – with no mention of the potential lives saved.

“Lockdowns just have one consequence that you must never ever belittle, and that is making poor people an awful lot poorer,” he said.

Dr. David Nabarro from the WHO appealed to world leaders yesterday, telling them to stop “using lockdowns as your primary control method”.Source:Twitter

“We in the World Health Organisation do not advocate lockdowns as the primary means of control of this virus,” Dr Nabarro told The Spectator.

“The only time we believe a lockdown is justified is to buy you time to reorganise, regroup, rebalance your resources, protect your health workers who are exhausted, but by and large, we’d rather not do it.”

Dr Nabarro’s main criticism of lockdowns involved the global impact, explaining how poorer economies that had been indirectly affected.

“Just look at what’s happened to the tourism industry in the Caribbean, for example, or in the Pacific because people aren’t taking their holidays,” he said.

“Look what’s happened to smallholder farmers all over the world. … Look what’s happening to poverty levels. It seems that we may well have a doubling of world poverty by next year. We may well have at least a doubling of child malnutrition.”

Melbourne’s lockdown has been hailed as one of the strictest and longest in the world. In Spain’s lockdown in March, people weren’t allowed to leave the house unless it was to walk their pet. In China, authorities welded doors shut to stop people from leaving their homes. The WHO thinks these steps were largely unnecessary.

Instead, Dr Nabarro is advocating for a new approach to containing the virus.

“And so, we really do appeal to all world leaders: stop using lockdown as your primary control method. Develop better systems for doing it. Work together and learn from each other.”

The WHO’s criticism of lockdowns involved the global impact, explaining how poorer economies that had been indirectly affected. Picture: Christopher Black/AFPSource:AFP

His message is timely. In a world first, a number of health experts from all over the world came together calling for an end to coronavirus lockdowns earlier this week.

They created a petition, called the Great Barrington Declaration, which said that lockdowns were doing “irreparable damage.”

“As infectious disease epidemiologists and public health scientists, we have grave concerns about the damaging physical and mental health impacts of the prevailing COVID-19 policies, and recommend an approach we call Focused Protection,” read the petition.

“Current lockdown policies are producing devastating effects on short and long-term public health.”

The petition has had 12,000 signatures so far.

It was authored by Sunetra Gupta of the University of Oxford, Jay Bhattacharya of Stanford University, and Martin Kulldorff of Harvard University.

When asked about the petition, Dr Nabarro had only good things to say. “Really important point by Professor Gupta,” he said.

This content was originally published here.


Diabetes drug Metformin recalled due to high level of cancer agent

The diabetes drug Metformin hydrochloride has been recalled because it contains excess levels of a cancer-causing agent, the U.S. Food and Drug Administration announced this week.

The drug’s manufacturer, Marksans Pharma Limited, has expanded a recall initially announced in June to now include an additional 76 unexpired lots of the medication.

The recalled drugs are marketed as “extended-release tablets” under the brand name Time-Cap Labs, Inc.

The drug helps lower the blood glucose levels of those with type 2 diabetes.

But the recalled product contained an unacceptably high level of N-Nitrosodimethylamine, which is considered a probable human carcinogen.

“Marksans performed N-Nitrosodimethylamine (NDMA) testing of unexpired identified marketed lots and observed that NDMA content in some lots is exceeding the acceptable Daily Intake Limit (ADI) of 96ng/day,” the FDA outlined in its announcement.

“Therefore, out of an abundance of caution, an additional 76 lots are being recalled.”

The recall applies to metformin tablets between 500 mg and 750 mg.

The 500 mg tablets are debossed with “101” on one side; the 750 mg tablets are debossed with “102” on one side, the agency said.

US health regulators are telling five drugmakers to recall their…

The FDA advises users to continue taking the recalled tablets until a medical professional provides a replacement or alternative treatment option.

“It could be dangerous for patients with type 2 diabetes to stop taking their metformin without first talking to their health care professional,” the FDA said in a statement.

Consumers “should contact their physician or healthcare provider if they have experienced any problems that may be related to taking or using this drug product.”

This content was originally published here.


Jane Fonda calls coronavirus ‘God’s gift to the left’

Jane Fonda calls coronavirus ‘God’s gift to the left’

This content was originally published here.


Biohacking Sex, Tantric Breathwork, Orgasmic Enhancement & More!

Jamie Wheal is a peak-performance expert who, in his new book, Recapture the Rapture: Rethinking God, Sex, and Death in a World That’s Lost Its Mind, maps out a revolutionary new practice that combines the best of neuroscience and optimal psychology. He calls it hedonic engineering, and it is an intensive program of breathing, movement, and sexuality that mends trauma, heightens inspiration, and tightens connections—helping us wake up, grow up, and show up for a world that needs us all.

For example, here’s a Hedonic Sex matrix, very similar to what Jamie and I unpack on today’s podcast:

Groundbreaking new research is demonstrating that we can shift our neurology and biology into peak states and radically upgrade not just our well-being but also our sexual experiences. The secret to biohacking sex is to combine breathing, moving, and sexuality into an intense program that can be used to break free from the stress, anxiety, and addiction that are destroying us and find a way back to mental health.

Jamie is an expert on peak performance and leadership who specializes in the neuroscience and application of flow states. He has advised everyone from the U.S. Naval War College and Special Operations Command, the athletes of RedBull, and the owners of NFL, NBA, MLB, and Premier League teams to the executives of Google, Goldman Sachs, Deloitte, Cisco, and Young Presidents’ Organization. He studied historical anthropology under MacArthur Fellow Patricia Nelson Limerick, specializing in utopian social movements, and his work has appeared in anthologies and peer-reviewed academic journals.

During this discussion, you’ll discover:

-Why Jamie wrote his latest book, Recapture the Rapture…07:55

-What the “flow state” has to do with sex and partner connectivity…11:35

-The evolutionary drivers that enable us to heal, inspire, and connect with other people…20:50

-The hedonic yoga matrices of becoming…24:40

-How to hack the air we breathe…36:15

-Biohacking sex with breathwork…54:13

-Gels, creams, lotions, plant medicines, etc. for biohacking sex that Jamie recommends…1:12:05

-And much more…

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Do you have questions, thoughts, or feedback for Jamie or me? Leave your comments below and one of us will reply!

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This content was originally published here.